一区二区三区无码动态图,精品国产小视频在线观看,www久久无码天堂mv,亚洲第一区二区三区av

歡迎進(jìn)入上海起發(fā)實(shí)驗(yàn)試劑有限公司!
產(chǎn)品展示
首頁 > 產(chǎn)品展示 > > ATRA > 理想而穩(wěn)定的維甲酸(ATRA)替代物

理想而穩(wěn)定的維甲酸(ATRA)替代物

描述:與全反式維甲酸(ATRA)不同,EC23在溶液狀態(tài)下對(duì)光線、加熱和空氣都不敏感。EC23不溶于水,微溶于乙醇,可以DMSO配制10mg/mL母液,或者以95%乙醇配制0.33mg/mL的母液,需要漩渦助溶。后續(xù)可溶于水溶液(包括細(xì)胞培養(yǎng)基)。溶液形式的EC23不會(huì)降解,保存EC23溶液時(shí)不必特別注意避光密封

更新時(shí)間:2016-12-12
訪問次數(shù):1873
廠商性質(zhì):代理商
詳情介紹

 

理想而穩(wěn)定的維甲酸(ATRA)替代物
   添加時(shí)間:2012-1-4 14:35:48


 

 

貨號(hào):SRP001
品名:合成的類維A EC23
(4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-ylethynyl) benzoic acid)
 
物理特性:
外觀:白色粉末
分子式:C23H24O2
分子量:332
純度:99%HPLC
 
保存:
合成的類維A EC23可以在常規(guī)實(shí)驗(yàn)室條件下保持化學(xué)/物理性質(zhì)的穩(wěn)定。
 
可溶性:
全反式維甲酸(ATRA)不同,EC23在溶液狀態(tài)下對(duì)光線、加熱和空氣都不敏感。EC23不溶于水,微溶于乙醇,可以DMSO配制10mg/mL母液,或者以95%乙醇配制0.33mg/mL的母液,需要漩渦助溶。后續(xù)可溶于水溶液(包括細(xì)胞培養(yǎng)基)。溶液形式的EC23不會(huì)降解,保存EC23溶液時(shí)不必特別注意避光密封。
 
應(yīng)用:
EC23僅限科研使用,不可用于臨床。實(shí)驗(yàn)表明,該化合物可以強(qiáng)力的誘導(dǎo)多能干細(xì)胞向神經(jīng)組織方向分化,與ATRA相比,EC23能夠穩(wěn)定的誘導(dǎo)大量神經(jīng)元分化。此外,EC23還能激活Hox基因轉(zhuǎn)錄子的表達(dá)。
參考文獻(xiàn):
  1. Christie V.B., Barnard, J.H.,] Bridgens, C.E., Batsanov, A.S., Cartmell, E.B., Collings, J.C., Maltman, D.J., Marder, T.B., Redfern, C.P.F., Whiting, A.P., Przyborski, S.A. (2008). Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Organic and Biomolecular Chemistry, 6, 3497-3507.
  2. Christie, V.B., Marder, T.B., Whiting, A., Przyborski, S.A. (2008). Role of retinoids in the adult nervous system and their therapeutic potential. Mini Reviews in Medicinal Chemistry, 8, 601-608.
  3. Barnard, J.H., Collings, J.C., Whiting, A., Przyborski, S.A., Marder, T.B. (2009). Synthetic retinoids: structure-activity relationships. Chemistry, 15, 11430-52.
  4. Maltman, D.J., Christie, V.B., Collings, J.C., Barnard, J.H., Fenyk, S., Marder, T.B., Whiting, A., Przyborski, S.A. (2009). Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Molecular Biosystems, 5, 458-471.
品名
貨號(hào)
規(guī)格
ec23
SRP002
1 x 5mg clear glass vial

 

Differentiating neurons from stem cells just got easier. 
 

 

Some retinoids can be troublesome, their lack of stability in light and susceptibility to degradation means it is impossible to know what dose you are really working with. 

ec23 is a synthetic retinoid which reproduciblyinduces neuronal differentiation toconsistently high levels than those achieved with other more common retinoids. 
 

ec23 is compley stable and the dose you add to your culture is exactly what you think it isevery time.

For ease of use, ec23 comes in a clear glass vial.

No more searching for your retinoid in dark glass. 
 

ec23 is a stable, synthetic retinoid which has been shown to be a potent inducer of both pluripotent stem cell and adult neuroprogenitor cell differentiation across a range of species.1-5

 

 

More neurons less guess work

 

 

 

 

ec23 is stable; NMR of ec23 during prolonged exposure to light demonstrates clearly ec23 remains compley intact.




 

1H NMR (500 MHz) spectrum (δ 7.20-8.10) of ec23 in D16-DMSO in a glass NMR tube after 3 days in the dark under air (top), versus 3 days exposure to fluorescent light (bottom).
 

 

 Catalogue number   Product description    Pack size  
 SRP002  ec23   5mg  Download Reinnervate Flyer (PDF)  


To order contact your local LGC Standards office or  atcc@lgcstandards.com

Selected publications

 

1.Christie V.B., et al (2008). Organic and Biomolecular Chemistry, 6, 3497-3507.
2.Blow, N. (2008). Nature, 451, 855-858.
3.Przyborski S.A.  (2008). European Pharmaceutical Review, 6, 36-39.
4.Barnard, J.H., et al (2009). Chemistry, 15, 11430-52.
5.Maltman, D.J., et al (2009). Molecular Biosystems, 5, 458-471.

 

 

reinnervate

留言框

  • 產(chǎn)品:

  • 您的單位:

  • 您的姓名:

  • 聯(lián)系電話:

  • 常用郵箱:

  • 省份:

  • 詳細(xì)地址:

  • 補(bǔ)充說明:

  • 驗(yàn)證碼:

    請(qǐng)輸入計(jì)算結(jié)果(填寫阿拉伯?dāng)?shù)字),如:三加四=7
国产乱码精品一区二区三区香蕉| 国产精品久久久久a v| 亚洲中文字幕偷拍第一页| 久久久久欧美精品| 伊人久久精品欧洲综合网| 色狠狠av线一区二区三区| ae86老司机在线观看| 99久久精品费| 国产精品美女久久久久妇| 日本一区二区三区无人区| 青青草精品一区二区不卡| 欧美成人免费观看在线看| 自由 日本语 热 亚洲人| 免费av一区二区三区| 久久国产加勒比精品无码| 国产同事露脸对白在线视频| 整片完整片视频欧美在线| 97国产在线一区二区精品| 精品极品国产呦在线观看| 久久久久久精品免费免费wei| 性欧美大战?久久久久久| 日本片免费观看一区二区| 精品人妻一区二区三区伊人| 国产亚洲综合网曝门系列| 另类小说亚洲综合和小说| 99国产精品国产精品久久| 亚洲一级特大黄| a天堂专区一区二区三区| H无码里番肉片在线观看| 91自国产精品中文字幕| 新97在线观看免费视频| 韩国无码av片在线观看网站| 日韩黄片天天看| 亚洲综合激情视频在线观看| 亚洲熟妇色xxxx亚洲| 日韩美女一区二区三区视频| www:久久久| 日本新人中文字幕在线观看| 日本成年人的免费午夜视频| 伊人久久综合无码成人网| sss亚洲国产天堂精品|